Drug interactions
Lisinopril + Metformin-repaglinide
Severity: Moderate
Lisinopril and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and increase the risk of hypoglycemia with antidiabetic drugs. They may also reduce renal function in susceptible patients, which could increase metformin accumulation and lactic acidosis risk.
What this interaction means in plain words
Lisinopril and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
ACE inhibition enhances insulin sensitivity via bradykinin effects and may reduce renal clearance of metformin when renal function declines.
What to do
Monitor blood glucose and renal function, especially at initiation, and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Lisinopril and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and increase the risk of hypoglycemia with antidiabetic drugs. They may also reduce renal function in susceptible patients, which could increase metformin accumulation and lactic acidosis risk.
How serious is the interaction between Lisinopril and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, especially at initiation, and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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