Drug interactions
Lisinopril + Tadalafil
Severity: Moderate
Lisinopril and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil can add to the antihypertensive effect of ACE inhibitors such as lisinopril. This may cause symptomatic hypotension, particularly at initiation or after dose changes.
What this interaction means in plain words
Lisinopril and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when tadalafil is started. Counsel patients on slow position changes and adjust doses if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Tadalafil?
MediHelp rates the interaction as moderate. Lisinopril and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil can add to the antihypertensive effect of ACE inhibitors such as lisinopril. This may cause symptomatic hypotension, particularly at initiation or after dose changes.
How serious is the interaction between Lisinopril and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when tadalafil is started. Counsel patients on slow position changes and adjust doses if hypotension develops.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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