Drug interactions
Lisinopril + Terazosin
Severity: Moderate
Lisinopril and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terazosin and lisinopril together can cause additive hypotension and an exaggerated first-dose response, leading to dizziness or syncope.
What this interaction means in plain words
Lisinopril and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Terazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic effect of alpha-1 blockade and ACE inhibition.
What to do
Start low, give the first dose at bedtime, and monitor sitting and standing blood pressure during titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Terazosin?
MediHelp rates the interaction as moderate. Lisinopril and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terazosin and lisinopril together can cause additive hypotension and an exaggerated first-dose response, leading to dizziness or syncope.
How serious is the interaction between Lisinopril and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start low, give the first dose at bedtime, and monitor sitting and standing blood pressure during titration.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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