Drug interactions
Lisocabtagene maraleucel + Ustekinumab
Severity: Moderate
Lisocabtagene maraleucel and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisocabtagene maraleucel is a CD19 CAR T-cell therapy with risks of prolonged cytopenia, hypogammaglobulinemia and serious infection. Concurrent ustekinumab could add to infection risk, though data are lacking.
What this interaction means in plain words
Lisocabtagene maraleucel and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisocabtagene maraleucel belongs to Oncology; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression between IL-12/IL-23 blockade and CAR T-related immune compromise; largely theoretical.
What to do
Consider holding ustekinumab around lymphodepletion and CAR T infusion. Monitor for infection and cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lisocabtagene maraleucel and Ustekinumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Lisocabtagene maraleucel
Frequently asked questions
Can I take Lisocabtagene maraleucel with Ustekinumab?
MediHelp rates the interaction as moderate. Lisocabtagene maraleucel and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisocabtagene maraleucel is a CD19 CAR T-cell therapy with risks of prolonged cytopenia, hypogammaglobulinemia and serious infection. Concurrent ustekinumab could add to infection risk, though data are lacking.
How serious is the interaction between Lisocabtagene maraleucel and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding ustekinumab around lymphodepletion and CAR T infusion. Monitor for infection and cytopenias.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
