Drug interactions
Lisuride + Quetiapine
Severity: Moderate
Lisuride and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine has D2 antagonist activity and may oppose the dopaminergic action of lisuride. Antagonism is weaker than with other antipsychotics, but loss of efficacy is possible, and lisuride can worsen psychosis.
What this interaction means in plain words
Lisuride and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between D2 blockade by quetiapine and D2 agonism by lisuride.
What to do
If an antipsychotic is needed alongside lisuride, quetiapine at the lowest effective dose is preferred; monitor motor symptoms and psychosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Lisuride with Quetiapine?
MediHelp rates the interaction as moderate. Lisuride and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine has D2 antagonist activity and may oppose the dopaminergic action of lisuride. Antagonism is weaker than with other antipsychotics, but loss of efficacy is possible, and lisuride can worsen psychosis.
How serious is the interaction between Lisuride and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antipsychotic is needed alongside lisuride, quetiapine at the lowest effective dose is preferred; monitor motor symptoms and psychosis.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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