Drug interactions
Lithium + Mifepristone
Severity: Moderate
Lithium and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone prolongs the QT interval in a dose-related manner and lithium has been associated with repolarization changes and bradyarrhythmias. Using them together may add to the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
What this interaction means in plain words
Lithium and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting. Repeat the ECG and monitor lithium levels during mifepristone therapy, particularly at higher doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Lithium with Mifepristone?
MediHelp rates the interaction as moderate. Lithium and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone prolongs the QT interval in a dose-related manner and lithium has been associated with repolarization changes and bradyarrhythmias. Using them together may add to the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
How serious is the interaction between Lithium and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting. Repeat the ECG and monitor lithium levels during mifepristone therapy, particularly at higher doses.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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