Drug interactions
Lithium + Oliceridine
Severity: Moderate
Lithium and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is an opioid and opioids combined with serotonergic agents like lithium carry a theoretical risk of serotonin syndrome. Additive CNS depression is also possible.
What this interaction means in plain words
Lithium and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Possible additive serotonergic activity and additive CNS depression; the serotonergic contribution of oliceridine is not well established.
What to do
Monitor for serotonin toxicity and excessive sedation, particularly when starting or increasing doses. Use the lowest effective opioid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Lithium with Oliceridine?
MediHelp rates the interaction as moderate. Lithium and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is an opioid and opioids combined with serotonergic agents like lithium carry a theoretical risk of serotonin syndrome. Additive CNS depression is also possible.
How serious is the interaction between Lithium and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and excessive sedation, particularly when starting or increasing doses. Use the lowest effective opioid dose.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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