Drug interactions
Lithium + Oxaprozin
Severity: Major
Lithium and Oxaprozin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can raise serum lithium concentrations, potentially leading to lithium toxicity with tremor, confusion, ataxia and gastrointestinal symptoms. The narrow therapeutic index makes this clinically important.
What this interaction means in plain words
Lithium and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lithium belongs to Central Nervous System; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAIDs reduce renal prostaglandin-dependent blood flow and lithium clearance, increasing lithium reabsorption.
What to do
Avoid the combination if possible; otherwise check lithium levels within about a week of starting and after any change, and reduce the lithium dose as needed. Counsel patients on signs of toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Oxaprozin?
MediHelp rates the interaction as major. Lithium and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can raise serum lithium concentrations, potentially leading to lithium toxicity with tremor, confusion, ataxia and gastrointestinal symptoms. The narrow therapeutic index makes this clinically important.
How serious is the interaction between Lithium and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise check lithium levels within about a week of starting and after any change, and reduce the lithium dose as needed. Counsel patients on signs of toxicity.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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