Drug interactions
Lithium + Tinidazole
Severity: Moderate
Lithium and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole, a related nitroimidazole, has been reported to raise serum lithium concentrations, and tinidazole may behave similarly although this is not well established. Elevated lithium can cause tremor, confusion, gastrointestinal upset and renal injury.
What this interaction means in plain words
Lithium and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Tinidazole belongs to Anti Parasitic.
Why it happens
The mechanism is not established; possible reduced renal lithium clearance, extrapolated from metronidazole.
What to do
Check serum lithium and creatinine within several days of starting tinidazole and reduce the lithium dose if levels rise. Advise the patient to report signs of lithium toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Tinidazole?
MediHelp rates the interaction as moderate. Lithium and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metronidazole, a related nitroimidazole, has been reported to raise serum lithium concentrations, and tinidazole may behave similarly although this is not well established. Elevated lithium can cause tremor, confusion, gastrointestinal upset and renal injury.
How serious is the interaction between Lithium and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum lithium and creatinine within several days of starting tinidazole and reduce the lithium dose if levels rise. Advise the patient to report signs of lithium toxicity.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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