Drug interactions
Lithium + Voclosporin
Severity: Moderate
Lithium and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QT interval at high exposures and may cause nephrotoxicity, and lithium also affects cardiac conduction and depends on renal clearance. Together they may increase arrhythmia risk and raise lithium levels if renal function declines.
What this interaction means in plain words
Lithium and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Additive effects on QT interval, and voclosporin-related reduction in renal function may reduce lithium clearance.
What to do
Monitor renal function and lithium levels regularly, and obtain an ECG if there are other QT risk factors. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Lithium with Voclosporin?
MediHelp rates the interaction as moderate. Lithium and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can prolong the QT interval at high exposures and may cause nephrotoxicity, and lithium also affects cardiac conduction and depends on renal clearance. Together they may increase arrhythmia risk and raise lithium levels if renal function declines.
How serious is the interaction between Lithium and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and lithium levels regularly, and obtain an ECG if there are other QT risk factors. Correct potassium and magnesium abnormalities.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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