Drug interactions
Lofepramine + Memantine-donepezil
Severity: Moderate
Lofepramine and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with anticholinergic properties, though weaker than many others. It may oppose donepezil's cholinergic effect and worsen cognition, and tricyclics can also affect cardiac conduction.
What this interaction means in plain words
Lofepramine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anticholinergic activity of the tricyclic antagonizes cholinesterase inhibition.
What to do
Consider a less anticholinergic antidepressant such as an SSRI. If lofepramine is needed, monitor cognition, heart rate and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Frequently asked questions
Can I take Lofepramine with Memantine-donepezil?
MediHelp rates the interaction as moderate. Lofepramine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with anticholinergic properties, though weaker than many others. It may oppose donepezil's cholinergic effect and worsen cognition, and tricyclics can also affect cardiac conduction.
How serious is the interaction between Lofepramine and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a less anticholinergic antidepressant such as an SSRI. If lofepramine is needed, monitor cognition, heart rate and ECG.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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