Drug interactions
Lofepramine + Metaxalone
Severity: Moderate
Lofepramine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with sedative properties, and it may add to the drowsiness caused by metaxalone. A serotonergic contribution has also been described with metaxalone, though it is uncommon.
What this interaction means in plain words
Lofepramine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with a possible minor serotonergic contribution.
What to do
Monitor for sedation, dizziness and anticholinergic effects, and reduce doses if needed. Watch for features of serotonin toxicity such as agitation, tremor or hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Lofepramine with Metaxalone?
MediHelp rates the interaction as moderate. Lofepramine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with sedative properties, and it may add to the drowsiness caused by metaxalone. A serotonergic contribution has also been described with metaxalone, though it is uncommon.
How serious is the interaction between Lofepramine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and anticholinergic effects, and reduce doses if needed. Watch for features of serotonin toxicity such as agitation, tremor or hyperthermia.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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