Drug interactions
Lofepramine + Nalbuphine
Severity: Moderate
Lofepramine and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with some sedative and anticholinergic properties and may add to nalbuphine CNS depression. Drowsiness and psychomotor impairment may be increased.
What this interaction means in plain words
Lofepramine and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from antihistaminic and anticholinergic effects plus opioid receptor activity.
What to do
Monitor sedation, particularly at initiation and in older patients, and reduce doses if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Lofepramine with Nalbuphine?
MediHelp rates the interaction as moderate. Lofepramine and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with some sedative and anticholinergic properties and may add to nalbuphine CNS depression. Drowsiness and psychomotor impairment may be increased.
How serious is the interaction between Lofepramine and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, particularly at initiation and in older patients, and reduce doses if drowsiness is excessive.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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