Drug interactions
Lofepramine + Oxymorphone
Severity: Moderate
Lofepramine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with some sedative and anticholinergic activity, which can add to opioid-induced drowsiness and respiratory depression. Serotonergic effects are possible but less established with oxymorphone.
What this interaction means in plain words
Lofepramine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, together with additive anticholinergic effects such as constipation and urinary retention.
What to do
Monitor for sedation, constipation and urinary retention, and begin with lower opioid doses. Review the combination if confusion or oversedation occurs, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Lofepramine with Oxymorphone?
MediHelp rates the interaction as moderate. Lofepramine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with some sedative and anticholinergic activity, which can add to opioid-induced drowsiness and respiratory depression. Serotonergic effects are possible but less established with oxymorphone.
How serious is the interaction between Lofepramine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, constipation and urinary retention, and begin with lower opioid doses. Review the combination if confusion or oversedation occurs, especially in older adults.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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