Drug interactions
Lofepramine + Propafenone
Severity: Moderate
Lofepramine and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits CYP2D6 and may raise concentrations of lofepramine and its active metabolite desipramine. Both drugs affect cardiac conduction, so risk of arrhythmia and tricyclic toxicity increases.
What this interaction means in plain words
Lofepramine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition by propafenone plus additive conduction and QT effects.
What to do
Use a lower lofepramine dose and monitor ECG and for anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Lofepramine with Propafenone?
MediHelp rates the interaction as moderate. Lofepramine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone inhibits CYP2D6 and may raise concentrations of lofepramine and its active metabolite desipramine. Both drugs affect cardiac conduction, so risk of arrhythmia and tricyclic toxicity increases.
How serious is the interaction between Lofepramine and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower lofepramine dose and monitor ECG and for anticholinergic effects.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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