Drug interactions
Lofepramine + Quetiapine
Severity: Moderate
Lofepramine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, and lofepramine, a tricyclic antidepressant, also has anticholinergic and cardiac effects. Together they may increase drowsiness, hypotension and QT prolongation risk. Quetiapine may also add to antidepressant-related anticholinergic burden.
What this interaction means in plain words
Lofepramine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedative, hypotensive and QT-prolonging pharmacodynamic effects.
What to do
Monitor sedation, blood pressure and ECG, particularly in older patients or those with cardiac disease. Reduce doses if excess sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Lofepramine with Quetiapine?
MediHelp rates the interaction as moderate. Lofepramine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, and lofepramine, a tricyclic antidepressant, also has anticholinergic and cardiac effects. Together they may increase drowsiness, hypotension and QT prolongation risk. Quetiapine may also add to antidepressant-related anticholinergic burden.
How serious is the interaction between Lofepramine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and ECG, particularly in older patients or those with cardiac disease. Reduce doses if excess sedation occurs.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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