Drug interactions
Lofepramine + Secobarbital
Severity: Moderate
Lofepramine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so together they can cause excessive drowsiness and impaired psychomotor performance. Barbiturate enzyme induction may also lower tricyclic antidepressant levels.
What this interaction means in plain words
Lofepramine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible barbiturate-induced hepatic metabolism of the tricyclic.
What to do
Counsel the patient about drowsiness and avoiding driving. Monitor antidepressant response and adjust the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Lofepramine with Secobarbital?
MediHelp rates the interaction as moderate. Lofepramine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so together they can cause excessive drowsiness and impaired psychomotor performance. Barbiturate enzyme induction may also lower tricyclic antidepressant levels.
How serious is the interaction between Lofepramine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about drowsiness and avoiding driving. Monitor antidepressant response and adjust the dose if needed.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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