Drug interactions
Lofepramine + Sumatriptan
Severity: Moderate
Lofepramine and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with serotonin and noradrenaline reuptake inhibition, so with sumatriptan it may rarely lead to serotonin syndrome. Its serotonergic effect is weaker than that of some other tricyclics.
What this interaction means in plain words
Lofepramine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity through reuptake inhibition and triptan 5-HT1 agonism.
What to do
Counsel on serotonin syndrome symptoms and monitor after starting or raising doses. Stop both drugs if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Lofepramine with Sumatriptan?
MediHelp rates the interaction as moderate. Lofepramine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with serotonin and noradrenaline reuptake inhibition, so with sumatriptan it may rarely lead to serotonin syndrome. Its serotonergic effect is weaker than that of some other tricyclics.
How serious is the interaction between Lofepramine and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on serotonin syndrome symptoms and monitor after starting or raising doses. Stop both drugs if symptoms appear.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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