Drug interactions
Lofepramine + Tiotropium
Severity: Moderate
Lofepramine and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with anticholinergic properties, though weaker than amitriptyline. Together with tiotropium it can add to dry mouth, constipation, urinary retention and blurred vision. Risk is higher in older patients.
What this interaction means in plain words
Lofepramine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects at muscarinic receptors.
What to do
Monitor for urinary retention, constipation and ocular symptoms, and take care in glaucoma or prostatic hypertrophy. Consider a less anticholinergic antidepressant if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lofepramine and Tiotropium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tiotropium
Frequently asked questions
Can I take Lofepramine with Tiotropium?
MediHelp rates the interaction as moderate. Lofepramine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with anticholinergic properties, though weaker than amitriptyline. Together with tiotropium it can add to dry mouth, constipation, urinary retention and blurred vision. Risk is higher in older patients.
How serious is the interaction between Lofepramine and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and ocular symptoms, and take care in glaucoma or prostatic hypertrophy. Consider a less anticholinergic antidepressant if adverse effects emerge.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
