Drug interactions
Lofepramine + Tolazamide
Severity: Minor
Lofepramine and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have occasionally been linked to altered glycemic control, and they may potentiate the effect of sulfonylureas. The effect is inconsistent and generally small, but hypoglycemia is possible in susceptible patients.
What this interaction means in plain words
Lofepramine and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive effect on glucose homeostasis; the mechanism is not clearly established.
What to do
Monitor blood glucose when lofepramine is started or stopped in a patient taking tolazamide. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Lofepramine with Tolazamide?
MediHelp rates the interaction as minor. Lofepramine and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have occasionally been linked to altered glycemic control, and they may potentiate the effect of sulfonylureas. The effect is inconsistent and generally small, but hypoglycemia is possible in susceptible patients.
How serious is the interaction between Lofepramine and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when lofepramine is started or stopped in a patient taking tolazamide. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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