Drug interactions
Lofexidine + Morphine
Severity: Moderate
Lofexidine and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine, a central alpha-2 agonist, can cause sedation, hypotension and bradycardia, which may add to the CNS depression of morphine. It is used to ease opioid withdrawal, so combined use is mostly during opioid tapering.
What this interaction means in plain words
Lofexidine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotensive effects from alpha-2 agonism and opioid agonism.
What to do
Monitor sedation, blood pressure and heart rate when used together. Avoid in patients with significant bradycardia or hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Morphine?
MediHelp rates the interaction as moderate. Lofexidine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine, a central alpha-2 agonist, can cause sedation, hypotension and bradycardia, which may add to the CNS depression of morphine. It is used to ease opioid withdrawal, so combined use is mostly during opioid tapering.
How serious is the interaction between Lofexidine and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and heart rate when used together. Avoid in patients with significant bradycardia or hypotension.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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