Drug interactions
Lofexidine + Nifedipine
Severity: Moderate
Lofexidine and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and lofexidine also slows heart rate. Combined use can produce additive hypotension, dizziness and bradycardia.
What this interaction means in plain words
Lofexidine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering from calcium channel blockade plus central alpha-2 agonism with sympatholytic bradycardic effects.
What to do
Monitor blood pressure and pulse when lofexidine is started or adjusted, and counsel on orthostatic symptoms. Reduce the dose of one drug if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lofexidine and Nifedipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nifedipine
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Nifedipine?
MediHelp rates the interaction as moderate. Lofexidine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and lofexidine also slows heart rate. Combined use can produce additive hypotension, dizziness and bradycardia.
How serious is the interaction between Lofexidine and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse when lofexidine is started or adjusted, and counsel on orthostatic symptoms. Reduce the dose of one drug if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
