Drug interactions
Lofexidine + Oxazepam
Severity: Moderate
Lofexidine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine causes sedation, hypotension and bradycardia, and combining it with oxazepam may increase drowsiness and dizziness. This is relevant in opioid withdrawal, where benzodiazepines are often used as well.
What this interaction means in plain words
Lofexidine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from alpha-2 agonism and GABA-A potentiation, with added hypotensive effect.
What to do
Monitor blood pressure, heart rate and sedation, and use the lowest effective oxazepam dose. Counsel on avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Oxazepam?
MediHelp rates the interaction as moderate. Lofexidine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine causes sedation, hypotension and bradycardia, and combining it with oxazepam may increase drowsiness and dizziness. This is relevant in opioid withdrawal, where benzodiazepines are often used as well.
How serious is the interaction between Lofexidine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation, and use the lowest effective oxazepam dose. Counsel on avoiding driving and alcohol.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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