Drug interactions
Lofexidine + Ramipril
Severity: Moderate
Lofexidine and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is a centrally acting alpha-2 agonist that lowers blood pressure and heart rate. With an ACE inhibitor, hypotension and bradycardia may be more pronounced, with a risk of dizziness and syncope.
What this interaction means in plain words
Lofexidine and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Ramipril belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through central sympatholytic action and inhibition of angiotensin II formation.
What to do
Monitor blood pressure and pulse, especially during lofexidine initiation and dose changes. Reduce the antihypertensive dose if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Ramipril?
MediHelp rates the interaction as moderate. Lofexidine and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is a centrally acting alpha-2 agonist that lowers blood pressure and heart rate. With an ACE inhibitor, hypotension and bradycardia may be more pronounced, with a risk of dizziness and syncope.
How serious is the interaction between Lofexidine and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse, especially during lofexidine initiation and dose changes. Reduce the antihypertensive dose if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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