Drug interactions
Lofexidine + Salmeterol
Severity: Moderate
Lofexidine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine can prolong the QT interval and cause bradycardia and hypotension. Salmeterol may add to repolarisation effects and lower potassium, increasing arrhythmia risk in susceptible patients.
What this interaction means in plain words
Lofexidine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist induced hypokalemia adding risk.
What to do
Monitor ECG and electrolytes in patients with cardiac risk factors, and correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Salmeterol?
MediHelp rates the interaction as moderate. Lofexidine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine can prolong the QT interval and cause bradycardia and hypotension. Salmeterol may add to repolarisation effects and lower potassium, increasing arrhythmia risk in susceptible patients.
How serious is the interaction between Lofexidine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac risk factors, and correct hypokalemia and hypomagnesemia.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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