Drug interactions
Lofexidine + Trandolapril
Severity: Moderate
Lofexidine and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers blood pressure and heart rate, and an ACE inhibitor adds to the hypotensive effect. Patients may develop symptomatic hypotension, dizziness or syncope, particularly at the start of treatment.
What this interaction means in plain words
Lofexidine and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Trandolapril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotension from central alpha-2 agonism and reduced angiotensin II formation.
What to do
Monitor blood pressure and heart rate during lofexidine treatment and consider reducing or holding the antihypertensive if hypotension or bradycardia develops. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lofexidine and Trandolapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Trandolapril?
MediHelp rates the interaction as moderate. Lofexidine and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine lowers blood pressure and heart rate, and an ACE inhibitor adds to the hypotensive effect. Patients may develop symptomatic hypotension, dizziness or syncope, particularly at the start of treatment.
How serious is the interaction between Lofexidine and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during lofexidine treatment and consider reducing or holding the antihypertensive if hypotension or bradycardia develops. Advise patients to rise slowly.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
