Drug interactions
Lonapegsomatropin + Prednisone
Severity: Moderate
Lonapegsomatropin and Prednisone: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which reduces conversion of cortisone to cortisol, and this can reduce the effect of cortisone-type glucocorticoids. Prednisone itself needs conversion to prednisolone by the same enzyme, so its effect may be reduced. Patients on glucocorticoid replacement may need higher doses after starting growth hormone.
What this interaction means in plain words
Lonapegsomatropin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonapegsomatropin belongs to Endocrine; Prednisone belongs to Endocrine.
Why it happens
Growth hormone inhibits 11-beta-HSD1, reducing activation of prednisone to prednisolone.
What to do
Monitor for signs of glucocorticoid insufficiency after starting lonapegsomatropin and increase the glucocorticoid dose if needed. Consider prednisolone or hydrocortisone-based regimens in adrenal insufficiency and reassess when GH dosing changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- Skytrofa - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Prednisone?
MediHelp rates the interaction as moderate. Lonapegsomatropin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which reduces conversion of cortisone to cortisol, and this can reduce the effect of cortisone-type glucocorticoids. Prednisone itself needs conversion to prednisolone by the same enzyme, so its effect may be reduced. Patients on glucocorticoid replacement may need higher doses after starting growth hormone.
How serious is the interaction between Lonapegsomatropin and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of glucocorticoid insufficiency after starting lonapegsomatropin and increase the glucocorticoid dose if needed. Consider prednisolone or hydrocortisone-based regimens in adrenal insufficiency and reassess when GH dosing changes.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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