Drug interactions
Lonapegsomatropin + Tolbutamide
Severity: Moderate
Lonapegsomatropin and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity, which can raise blood glucose and weaken the effect of tolbutamide. Patients with diabetes may need dose adjustment of antihyperglycemic therapy.
What this interaction means in plain words
Lonapegsomatropin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonapegsomatropin belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism due to growth hormone-induced insulin resistance.
What to do
Monitor blood glucose when starting or changing the dose of lonapegsomatropin and increase the tolbutamide dose or add therapy as needed. Reassess if the growth hormone is stopped, because hypoglycemia risk may rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lonapegsomatropin and Tolbutamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Tolbutamide?
MediHelp rates the interaction as moderate. Lonapegsomatropin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity, which can raise blood glucose and weaken the effect of tolbutamide. Patients with diabetes may need dose adjustment of antihyperglycemic therapy.
How serious is the interaction between Lonapegsomatropin and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing the dose of lonapegsomatropin and increase the tolbutamide dose or add therapy as needed. Reassess if the growth hormone is stopped, because hypoglycemia risk may rise.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
