Drug interactions
Lonapegsomatropin + Warfarin
Severity: Minor
Lonapegsomatropin and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase the activity of some CYP450 enzymes, potentially lowering warfarin exposure and its anticoagulant effect. The clinical significance is not well characterized.
What this interaction means in plain words
Lonapegsomatropin and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonapegsomatropin belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
Possible induction of CYP450-mediated metabolism by growth hormone; data are limited.
What to do
Check INR after starting or stopping lonapegsomatropin and adjust the warfarin dose if the INR changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Warfarin?
MediHelp rates the interaction as minor. Lonapegsomatropin and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase the activity of some CYP450 enzymes, potentially lowering warfarin exposure and its anticoagulant effect. The clinical significance is not well characterized.
How serious is the interaction between Lonapegsomatropin and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR after starting or stopping lonapegsomatropin and adjust the warfarin dose if the INR changes.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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