Drug interactions
Albuterol + Loperamide
Severity: Moderate
Albuterol and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, loperamide especially at supratherapeutic doses, and albuterol can also cause hypokalemia and tachycardia. Together they may raise the risk of ventricular arrhythmia, mainly in susceptible patients.
What this interaction means in plain words
Albuterol and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with albuterol-induced hypokalemia potentially adding to the risk.
What to do
Use loperamide only at labeled doses, and check potassium and magnesium in patients with other QT risk factors. Obtain an ECG if palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Frequently asked questions
Can I take Albuterol with Loperamide?
MediHelp rates the interaction as moderate. Albuterol and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, loperamide especially at supratherapeutic doses, and albuterol can also cause hypokalemia and tachycardia. Together they may raise the risk of ventricular arrhythmia, mainly in susceptible patients.
How serious is the interaction between Albuterol and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use loperamide only at labeled doses, and check potassium and magnesium in patients with other QT risk factors. Obtain an ECG if palpitations or syncope occur.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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