Drug interactions
Anagrelide + Loperamide
Severity: Major
Anagrelide and Loperamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combining them raises the risk of ventricular arrhythmia including torsades de pointes. The risk rises with high loperamide doses.
What this interaction means in plain words
Anagrelide and Loperamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation through cardiac ion channel effects.
What to do
Avoid if possible and do not exceed labeled loperamide doses. Monitor ECG and correct electrolyte abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Loperamide
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Loperamide?
MediHelp rates the interaction as major. Anagrelide and Loperamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval, so combining them raises the risk of ventricular arrhythmia including torsades de pointes. The risk rises with high loperamide doses.
How serious is the interaction between Anagrelide and Loperamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and do not exceed labeled loperamide doses. Monitor ECG and correct electrolyte abnormalities.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Artemether / lumefantrine. The full list is on the Loperamide page.
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