Drug interactions
Amiodarone + Loperamide
Severity: Major
Amiodarone and Loperamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein and may raise systemic loperamide exposure. Both drugs also prolong QT, so the arrhythmia risk is additive.
What this interaction means in plain words
Amiodarone and Loperamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Loperamide belongs to Gastrointestinal Tract.
Why it happens
P-gp inhibition increases loperamide absorption and central exposure, plus additive QT prolongation.
What to do
Avoid doses of loperamide above labeled limits and consider alternatives for diarrhea. Monitor ECG and electrolytes if combined.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Loperamide
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Loperamide?
MediHelp rates the interaction as major. Amiodarone and Loperamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone inhibits P-glycoprotein and may raise systemic loperamide exposure. Both drugs also prolong QT, so the arrhythmia risk is additive.
How serious is the interaction between Amiodarone and Loperamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid doses of loperamide above labeled limits and consider alternatives for diarrhea. Monitor ECG and electrolytes if combined.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amisulpride, Anagrelide, Artemether / lumefantrine. The full list is on the Loperamide page.
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