Drug interactions
Loprazolam + Oxymorphone
Severity: Major
Loprazolam and Oxymorphone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and benzodiazepines together cause additive sedation and respiratory depression that can result in coma or death. The risk rises with higher doses and in elderly or respiratory-compromised patients.
What this interaction means in plain words
Loprazolam and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via mu-opioid agonism and GABA-A potentiation.
What to do
Avoid combined use where possible; if necessary, use the lowest effective doses for the shortest duration and monitor respiration and sedation. Consider prescribing naloxone and counsel on alcohol avoidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Loprazolam with Oxymorphone?
MediHelp rates the interaction as major. Loprazolam and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids and benzodiazepines together cause additive sedation and respiratory depression that can result in coma or death. The risk rises with higher doses and in elderly or respiratory-compromised patients.
How serious is the interaction between Loprazolam and Oxymorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible; if necessary, use the lowest effective doses for the shortest duration and monitor respiration and sedation. Consider prescribing naloxone and counsel on alcohol avoidance.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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