Drug interactions
Loprazolam + Ramelteon
Severity: Moderate
Loprazolam and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loprazolam is a hypnotic benzodiazepine, and combining it with ramelteon may increase sedation and next-day impairment. Combined hypnotic use is rarely necessary.
What this interaction means in plain words
Loprazolam and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and melatonin receptor agonism.
What to do
Avoid using two hypnotics together where possible; if combined, use the lowest effective doses and monitor for daytime drowsiness and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Loprazolam with Ramelteon?
MediHelp rates the interaction as moderate. Loprazolam and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loprazolam is a hypnotic benzodiazepine, and combining it with ramelteon may increase sedation and next-day impairment. Combined hypnotic use is rarely necessary.
How serious is the interaction between Loprazolam and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two hypnotics together where possible; if combined, use the lowest effective doses and monitor for daytime drowsiness and falls.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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