Drug interactions
Loprazolam + Ziprasidone
Severity: Moderate
Loprazolam and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines and antipsychotics both cause sedation, so the combination can cause excess drowsiness, psychomotor impairment and hypotension. Falls and impaired driving are the main concerns, particularly in older patients.
What this interaction means in plain words
Loprazolam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects via GABA-A potentiation and antipsychotic antihistaminergic and adrenergic actions.
What to do
Use the lowest effective doses and monitor for oversedation and orthostatic hypotension. Counsel patients to avoid alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Loprazolam with Ziprasidone?
MediHelp rates the interaction as moderate. Loprazolam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines and antipsychotics both cause sedation, so the combination can cause excess drowsiness, psychomotor impairment and hypotension. Falls and impaired driving are the main concerns, particularly in older patients.
How serious is the interaction between Loprazolam and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and orthostatic hypotension. Counsel patients to avoid alcohol and driving until the response is known.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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