Drug interactions
Lorazepam + Orlistat
Severity: Minor
Lorazepam and Orlistat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat reduces fat absorption and has been associated with reduced absorption of some drugs, with reports of seizures in patients on antiepileptics. A clinically significant effect on lorazepam is not well established, so any reduction in benzodiazepine effect would be unpredictable.
What this interaction means in plain words
Lorazepam and Orlistat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lorazepam belongs to Central Nervous System; Orlistat belongs to Miscellaneous.
Why it happens
Possible reduced gastrointestinal absorption due to orlistat's lipase inhibition; not well established for lorazepam.
What to do
Monitor clinical response to lorazepam, particularly if used for seizure control or withdrawal prevention. Consider separating dosing by a few hours.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Other interactions of Orlistat
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
- Cholecalciferol + Orlistat Moderate
Frequently asked questions
Can I take Lorazepam with Orlistat?
MediHelp rates the interaction as minor. Lorazepam and Orlistat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Orlistat reduces fat absorption and has been associated with reduced absorption of some drugs, with reports of seizures in patients on antiepileptics. A clinically significant effect on lorazepam is not well established, so any reduction in benzodiazepine effect would be unpredictable.
How serious is the interaction between Lorazepam and Orlistat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to lorazepam, particularly if used for seizure control or withdrawal prevention. Consider separating dosing by a few hours.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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