Drug interactions
Lorcaserin + Maprotiline
Severity: Moderate
Lorcaserin and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin inhibits CYP2D6 and maprotiline is largely cleared by this enzyme, so maprotiline levels may rise. Both drugs also act on serotonergic pathways, and higher maprotiline exposure raises the risk of seizures, sedation and cardiac effects.
What this interaction means in plain words
Lorcaserin and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated maprotiline metabolism by lorcaserin, with possible additive serotonergic effects.
What to do
Monitor for maprotiline toxicity, including anticholinergic effects, sedation and ECG changes, and consider a lower maprotiline dose. Watch for serotonin syndrome features.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Lorcaserin with Maprotiline?
MediHelp rates the interaction as moderate. Lorcaserin and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorcaserin inhibits CYP2D6 and maprotiline is largely cleared by this enzyme, so maprotiline levels may rise. Both drugs also act on serotonergic pathways, and higher maprotiline exposure raises the risk of seizures, sedation and cardiac effects.
How serious is the interaction between Lorcaserin and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for maprotiline toxicity, including anticholinergic effects, sedation and ECG changes, and consider a lower maprotiline dose. Watch for serotonin syndrome features.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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