Drug interactions
Lorcaserin + Metaxalone
Severity: Minor
Lorcaserin and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin inhibits CYP2D6, but metaxalone is mainly cleared by other CYP enzymes, so a meaningful rise in metaxalone exposure is unlikely. Both agents can affect serotonergic tone and cause dizziness or sedation, but the combination is not well characterised.
What this interaction means in plain words
Lorcaserin and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lorcaserin weakly inhibits CYP2D6, which plays at most a minor role in metaxalone metabolism; a serotonergic contribution is theoretical.
What to do
No dose change is needed. Monitor for dizziness, sedation or signs of serotonin excess if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Lorcaserin with Metaxalone?
MediHelp rates the interaction as minor. Lorcaserin and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorcaserin inhibits CYP2D6, but metaxalone is mainly cleared by other CYP enzymes, so a meaningful rise in metaxalone exposure is unlikely. Both agents can affect serotonergic tone and cause dizziness or sedation, but the combination is not well characterised.
How serious is the interaction between Lorcaserin and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for dizziness, sedation or signs of serotonin excess if symptoms appear.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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