Drug interactions
Lorcaserin + Naratriptan
Severity: Moderate
Lorcaserin and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic activity, so combining them could lead to serotonin syndrome. Documented cases are rare, but labeling cautions about the combination. Lorcaserin has been withdrawn from the US market.
What this interaction means in plain words
Lorcaserin and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from 5-HT2C agonism by lorcaserin and 5-HT1B/1D agonism by the triptan.
What to do
If used together, monitor for serotonin syndrome after dose changes. Stop one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Lorcaserin with Naratriptan?
MediHelp rates the interaction as moderate. Lorcaserin and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic activity, so combining them could lead to serotonin syndrome. Documented cases are rare, but labeling cautions about the combination. Lorcaserin has been withdrawn from the US market.
How serious is the interaction between Lorcaserin and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If used together, monitor for serotonin syndrome after dose changes. Stop one agent if symptoms occur.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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