Drug interactions
Lorcaserin + Nebivolol
Severity: Moderate
Lorcaserin and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin inhibits CYP2D6, which may raise nebivolol concentrations, with potential for bradycardia and hypotension. Lorcaserin has been withdrawn in many markets.
What this interaction means in plain words
Lorcaserin and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated nebivolol metabolism.
What to do
Monitor heart rate and blood pressure and reduce the nebivolol dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Lorcaserin with Nebivolol?
MediHelp rates the interaction as moderate. Lorcaserin and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorcaserin inhibits CYP2D6, which may raise nebivolol concentrations, with potential for bradycardia and hypotension. Lorcaserin has been withdrawn in many markets.
How serious is the interaction between Lorcaserin and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and reduce the nebivolol dose if needed.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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