Drug interactions
Lorcaserin + Sertraline
Severity: Major
Lorcaserin and Sertraline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist, and combining it with an SSRI may increase the risk of serotonin syndrome. Lorcaserin has been withdrawn from several markets, including the US, so the combination is now rarely encountered.
What this interaction means in plain words
Lorcaserin and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic activity through 5-HT2C agonism and serotonin reuptake inhibition.
What to do
Avoid concurrent use; if unavoidable, monitor for agitation, tremor, hyperthermia, clonus and autonomic instability. Stop lorcaserin if serotonin syndrome is suspected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Lorcaserin with Sertraline?
MediHelp rates the interaction as major. Lorcaserin and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorcaserin is a serotonin 5-HT2C agonist, and combining it with an SSRI may increase the risk of serotonin syndrome. Lorcaserin has been withdrawn from several markets, including the US, so the combination is now rarely encountered.
How serious is the interaction between Lorcaserin and Sertraline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; if unavoidable, monitor for agitation, tremor, hyperthermia, clonus and autonomic instability. Stop lorcaserin if serotonin syndrome is suspected.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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