Drug interactions
Lorcaserin + Ziprasidone
Severity: Moderate
Lorcaserin and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, and using them together may raise the risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability. Lorcaserin has been withdrawn from many markets, so the pair is mainly of historical relevance.
What this interaction means in plain words
Lorcaserin and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects, with lorcaserin as a 5-HT2C agonist and ziprasidone as a 5-HT receptor antagonist and weak serotonin reuptake inhibitor; the interaction is largely theoretical.
What to do
Monitor for signs of serotonin toxicity such as clonus, hyperthermia and agitation. Stop lorcaserin if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Lorcaserin with Ziprasidone?
MediHelp rates the interaction as moderate. Lorcaserin and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, and using them together may raise the risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability. Lorcaserin has been withdrawn from many markets, so the pair is mainly of historical relevance.
How serious is the interaction between Lorcaserin and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as clonus, hyperthermia and agitation. Stop lorcaserin if symptoms develop.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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