Drug interactions
Lorlatinib + Lumateperone
Severity: Major
Lorlatinib and Lumateperone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may lower lumateperone concentrations via CYP3A4 induction, which can reduce antipsychotic efficacy. Lumateperone labeling advises against use with CYP3A4 inducers.
What this interaction means in plain words
Lorlatinib and Lumateperone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lorlatinib belongs to Oncology; Lumateperone belongs to Central Nervous System.
Why it happens
Lorlatinib induces CYP3A4, increasing lumateperone metabolism.
What to do
Avoid the combination; choose an alternative antipsychotic or monitor closely for relapse.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Lumateperone
Frequently asked questions
Can I take Lorlatinib with Lumateperone?
MediHelp rates the interaction as major. Lorlatinib and Lumateperone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorlatinib may lower lumateperone concentrations via CYP3A4 induction, which can reduce antipsychotic efficacy. Lumateperone labeling advises against use with CYP3A4 inducers.
How serious is the interaction between Lorlatinib and Lumateperone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose an alternative antipsychotic or monitor closely for relapse.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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