Drug interactions
Lorlatinib + Netupitant-palonosetron
Severity: Moderate
Lorlatinib and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and may lower netupitant exposure, which is cleared mainly by CYP3A4. Reduced netupitant levels could weaken antiemetic protection against chemotherapy-induced nausea and vomiting.
What this interaction means in plain words
Lorlatinib and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
Lorlatinib induces CYP3A4, increasing the metabolism of netupitant.
What to do
Monitor for breakthrough nausea and vomiting and add rescue antiemetics if needed. No empirical dose change of netupitant-palonosetron is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Lorlatinib and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a moderate CYP3A inducer and may lower netupitant exposure, which is cleared mainly by CYP3A4. Reduced netupitant levels could weaken antiemetic protection against chemotherapy-induced nausea and vomiting.
How serious is the interaction between Lorlatinib and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting and add rescue antiemetics if needed. No empirical dose change of netupitant-palonosetron is required.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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