Drug interactions
Lorlatinib + Nifedipine
Severity: Moderate
Lorlatinib and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and can lower nifedipine concentrations. This may reduce blood pressure or angina control.
What this interaction means in plain words
Lorlatinib and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Lorlatinib induces CYP3A4, increasing nifedipine metabolism.
What to do
Monitor blood pressure and angina symptoms and increase the nifedipine dose if needed. Reassess the dose if lorlatinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Nifedipine?
MediHelp rates the interaction as moderate. Lorlatinib and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a moderate CYP3A inducer and can lower nifedipine concentrations. This may reduce blood pressure or angina control.
How serious is the interaction between Lorlatinib and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and angina symptoms and increase the nifedipine dose if needed. Reassess the dose if lorlatinib is stopped.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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