Drug interactions
Lorlatinib + Nilotinib
Severity: Moderate
Lorlatinib and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A4 inducer and can reduce nilotinib concentrations, potentially lowering antileukemic efficacy. Lorlatinib itself can also prolong the PR interval.
What this interaction means in plain words
Lorlatinib and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
Induction of CYP3A4 metabolism of nilotinib by lorlatinib.
What to do
Monitor molecular response to nilotinib and consider nilotinib levels where available. Obtain an ECG at baseline and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Nilotinib?
MediHelp rates the interaction as moderate. Lorlatinib and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a moderate CYP3A4 inducer and can reduce nilotinib concentrations, potentially lowering antileukemic efficacy. Lorlatinib itself can also prolong the PR interval.
How serious is the interaction between Lorlatinib and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor molecular response to nilotinib and consider nilotinib levels where available. Obtain an ECG at baseline and during therapy.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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