Drug interactions
Lorlatinib + Palovarotene
Severity: Moderate
Lorlatinib and Palovarotene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palovarotene is cleared mainly by CYP3A4, and lorlatinib can induce this enzyme. Lower palovarotene exposure may reduce its efficacy in limiting heterotopic ossification.
What this interaction means in plain words
Lorlatinib and Palovarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Palovarotene belongs to Miscellaneous.
Why it happens
Lorlatinib induces CYP3A4, accelerating palovarotene metabolism.
What to do
Avoid the combination where possible; if used together, monitor for reduced palovarotene efficacy and review therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Lorlatinib with Palovarotene?
MediHelp rates the interaction as moderate. Lorlatinib and Palovarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palovarotene is cleared mainly by CYP3A4, and lorlatinib can induce this enzyme. Lower palovarotene exposure may reduce its efficacy in limiting heterotopic ossification.
How serious is the interaction between Lorlatinib and Palovarotene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used together, monitor for reduced palovarotene efficacy and review therapy.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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