Drug interactions
Lorlatinib + Ponesimod
Severity: Moderate
Lorlatinib and Ponesimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can slow heart rate or prolong AV conduction, so combined use may cause additive bradycardia or heart block. Ponesimod labeling advises caution with other heart-rate-lowering drugs.
What this interaction means in plain words
Lorlatinib and Ponesimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Ponesimod belongs to Central Nervous System.
Why it happens
Additive negative chronotropic and dromotropic effects, via S1P receptor modulation and lorlatinib-related bradycardia and PR prolongation.
What to do
Monitor heart rate and ECG, especially when starting ponesimod. Seek cardiology advice if baseline bradycardia or conduction disease is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Ponesimod
- Fingolimod + Ponesimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Amiodarone + Ponesimod Major
- Amisulpride + Ponesimod Major
- Anagrelide + Ponesimod Major
- Anti-thymocyte + Ponesimod Major
Frequently asked questions
Can I take Lorlatinib with Ponesimod?
MediHelp rates the interaction as moderate. Lorlatinib and Ponesimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can slow heart rate or prolong AV conduction, so combined use may cause additive bradycardia or heart block. Ponesimod labeling advises caution with other heart-rate-lowering drugs.
How serious is the interaction between Lorlatinib and Ponesimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, especially when starting ponesimod. Seek cardiology advice if baseline bradycardia or conduction disease is present.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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