Drug interactions
Lorlatinib + Praziquantel
Severity: Moderate
Lorlatinib and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may reduce praziquantel exposure, risking treatment failure. Praziquantel is only given for a short period, limiting duration of exposure.
What this interaction means in plain words
Lorlatinib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Praziquantel belongs to Anti Parasitic.
Why it happens
Lorlatinib induces CYP3A4, increasing praziquantel clearance.
What to do
Monitor for response to praziquantel and consider retreatment if cure is not confirmed. Temporary interruption of lorlatinib is rarely practical, so involve the oncologist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Praziquantel?
MediHelp rates the interaction as moderate. Lorlatinib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and may reduce praziquantel exposure, risking treatment failure. Praziquantel is only given for a short period, limiting duration of exposure.
How serious is the interaction between Lorlatinib and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for response to praziquantel and consider retreatment if cure is not confirmed. Temporary interruption of lorlatinib is rarely practical, so involve the oncologist.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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