Drug interactions
Lorlatinib + Trabectedin
Severity: Moderate
Lorlatinib and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may reduce trabectedin exposure, possibly reducing its efficacy.
What this interaction means in plain words
Lorlatinib and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Trabectedin belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing metabolism of trabectedin, a CYP3A4 substrate.
What to do
Monitor for reduced tumor response. Prefer coadministration with non-inducing agents when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Trabectedin
Frequently asked questions
Can I take Lorlatinib with Trabectedin?
MediHelp rates the interaction as moderate. Lorlatinib and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may reduce trabectedin exposure, possibly reducing its efficacy.
How serious is the interaction between Lorlatinib and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tumor response. Prefer coadministration with non-inducing agents when possible.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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